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Transcriptional regulation of adaptive NK and CD8 T cell responses [RNA-Seq]
- Alternate Title(s)
- Regulation of natural killer cells during MCMV infection
- Authors
- Lau, Colleen M.Sun, Joseph C.
- Description
Natural killer (NK) cells are innate lymphocytes that possess features of adaptive immunity such as clonal expansion and generation of long-lived memory. Here we look at transcriptional profiles of NK cells throughout several time points during MCMV infection, ex-vivo cytokine stimulation, and/or deficiency of key transcription factors such as STAT4, STAT1, and Runx1. In addition, we profile parallel...
- Subject
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Killer Cells, NaturalMouse CytomegalovirusT-Lymphocytes, CytotoxicTranscription FactorsViral Infections
- Access Rights
- Free to All
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Transcription factor IRF8 orchestrates the adaptive natural killer cell response
- Authors
- Lau, Colleen M.Sun, Joseph C.
- Description
RNA-seq performed on NK cells harvested during in-vivo infection. Natural killer (NK) cells are innate lymphocytes that have been recently appreciated to display features of adaptive immunity in response to viral infection. Biallelic mutations in the IRF8 gene have been reported to cause familial NK cell deficiency and susceptibility to severe viral infection in humans; however, the precise role...
- Subject
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Interferon Regulatory FactorsKiller Cells, NaturalMouse CytomegalovirusViral Infections
- Access Rights
- Free to All
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Effect of loss of Jmjd1c on MLL-AF9 leukemia
- Authors
- Zhu, NanRahnamay, Noushin F.Sinha, Amit U.Koche, Richard Patrick1 more author(s)...
- Description
Summary from GEO: "Analysis of gene expression profile of MLL-AF9 leukemia cells 6 days after loss of Jmjd1c. Loss of Jmjd1c induces differentiation and apoptosis in MLL-AF9 leukemia cells. These results provide insight into the role of Jmjd1c in MLL leukemia." Overall design from GEO: "We used primary Jmjd1c f/f MLL-AF9-GFP leukemia cells from four leukemic mice and delivered Cre-Tomato by retroviral...
- Subject
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Gene ExpressionJumonji Domain-Containing Histone DemethylasesLeukemia, Myeloid, AcuteRNA-SeqViral Infections
- Access Rights
- Free to All